Yongchao Fu

Contact Information

E

mail: 3212418315@qq.com;
Homepage: https://s0521.github.io.

Brief Biography

Yongchao Fu is an application engineer in Phoenix software working at Tri-ibiotech. Science and Technology with a bachelor’s degree. He have organized a lot of WinNonlin, NLME and NONME workshops.

Research Interests

Pharmacokinetics, pharmacodynamics, modeling and simulation, nonlinear mixed-effects model, quantitative computing, statistical computing, statistical reporting, reproducible reporting.

Education Background

2010~2013, Bachelor degree, biotechnology, Henan University of Science and Technology 2010~2013, College degree,Biopharmaceutical, Henan University of Animal Husbandry and Economics

Professional Experience

2013-2017, I join Chempartner as a Study Director Assistant, responsible for pre-clinical in vivo pharmacokinetics research in the DMPK department, including study protocol writing, study data analysis, study report writing, etc.

2017, I join Tri-ibiotech as an application engineer for Phoenix, and provide technical support and training services for users across the country.

• I hosted 11 WinNonlin workshops as the only lecturer,
• organized 2 NLME workshop with others,
• 5 NONMEM workshops with others,
• conducted internal training for dozens of companies,
• Help customer translate their NONMEM model to PML model,
• Help customer Building a entero-hepatic reflux model,
• Help analyze fish PK data.

I also made some Phoenix cases published on the company’s website, such as:

• how to use Phoenix to generate VPC Plot,
• how to use Phoenix for allometric scaling,
• how to use Phoenix building the Target-mediated drug disposition models.

Software Packages

R packages:

I’m the creator and main author of:

• guiplot: a user-friendly plotting aids based on graphical interface in R

R shiny:

I’m the creator and main author of:

• ERAT: ER analysis: used in the study of early clinical exposure - response data modeling analysis and analysis of covariate search tool.
• cqt_eda: C-QT analysis: used for modeling and analyzing the concentration–electrocardiogram QT interval (C-QT) correlation.

Website(Javascript):

I’m the creator and main author of:

• furt: Visualization plots of concentrations related to first-in-human trials.
• hedv: Human equivalent dose calculations based on guideline methods.
• dedireck: Transformation of animal pharmacokinetic curves to human pharmacokinetic curves, including dedireck and inverse dedireck plots.
• ConcToDose: From concentration to dose, estimation of dose based on some PK parameters.
• Conc+Model→Dose: From concentration to dose, estimation of dose based on PK models.

Extension:

I’m the creator and main author of:

• nonmem_cn：A Visual Studio Code extension that implements some basic language features of NONMEM code (syntax highlighting, auto-completion, etc.).

Phoenix case in Chinese

• Phoenix (WinNonlin NLME IVIVC toolkit) Q&A
• Interpretation of Phoenix WinNonlin Bioequivalence Results
• PML Series (1) Mini PBPK Model of Monoclonal Antibody
• Application PhoenixNLME simulates individual blood concentration
• VPC visual prediction check (1) conceptual principle
• VPC visual prediction check (2) draw VPC plot in Phoenix NLME
• VPC visual prediction check (3) hand-drawn VPC plot in Phoenix
• PML Series (2): Target-mediated drug disposition Model (TMDD)
• PML Series (3): Approximation of the TMDD Model
• PML Series (4): Simple Allometric scaling
• PML Series (5): Simple Allometric scaling(2)
• Phoenix Friendly Compatibility: Links to Phoenix and R Languages